The first time I tried to get to Hell I didn't go into the Prefab Building and instead just followed Sue but that's an entirely different story
Also keep in mind that I traded for the Machine Gun, didn't grab the Nemesis, and was playing on Easy Mode
B1: Took me five tries to realize that I had to use the Booster 2.0 to get past the spike traps, took me another five to start refreshing the Booster with the small spike, took me another five to actually get through
B2: Didn't ever die here but would lose at least half of my health every time
B3: The angels killed me more times than I can count. Quickly found out how useful the Machine Gun was (not at all) so most attacking was done by Curly. Managed to get to the Heavy Press (without the missile upgrade because I missed it), just stood in the middle and spammed missiles, then I get crushed. A couple more tries, avoided getting crushed, and got to Ballos
Ballos: Blade spam for the first phase, then I get crushed by the second phase at low health and die. After trying again and avoiding him, I learned the strategy of "point Curly at the eye and spam". Used the Life Pot (if I didn't after the first phase) but still managed to get beaten by the third phase. After a lot of tries to keep more and more health before Ballos, I learn how to actually avoid him, beat that phase, aand get killed by the spikes out of the ground. Even more tries and, after getting lucky with my health, I eventually got past the last phase and boom, best ending.
TL;DR spent 3 hours getting my butt kicked before getting lucky and making it out