Pixel didn't give Misery the ability to compensate for your attacks! The only one who does that kinda is Curly with missiles, Core with getting too close/too much damage at once, uh is that all?
You could say unless it is a cutscene, then you are only given an impression of the actual battle. If you wanted a true battle between Misery and Quote, first off; Misery wouldn't probably do the same thing twice. She'd learn from Quote's attacks, and become more difficult to defeat the longer it takes you.
If she bubbled you; you could probably bust out if you shoot it enough... but if she had bubbled you over some spikes...

Or if she had bubbled you then lightning striked the bubble..!
Point is, you got an impression of the great battle against Misery... Think of it as someone telling a story... "And Misery summoned bolts of lightning to follow Quote! And just when he dodged them, a giant boulder was sent flying at him!" compared to actually seeing what happened.
(Same goes for why all creatures look the same, act the same; same for why each type of texture has the same exact texture...)
We aren't seeing a real life Cave Story, but Pixel's retelling of Cave Story.
Otherwise...
If you defeat Misery reallllly fast, then she only gets to try each attack once, and you're just that good.
(Fly over her head unleashing a fully powered spur downward, then switch to lvl 3 blade and unleash, then as you pass through her switch to super missile and pow, pow, pow! all in one shot! Can't dodge that kind of kill!)