1) The Mac equivalent of "profiles.dat" is found here:
Library/Preferences/com.nakiwo.Doukutsu.plist
2) The beginning of this file is prefixed with about 402 bytes of Mac-specific stuff. However, at about hex 0x192, you start to see the same data as you would with the normal "profiles.dat" file.
3) The byte-order is reversed on Macs. So in the Windows version, the value "9999" has to be written "0f 27". In the Mac version, you have to write it "27 0f".
4) You have to completely close and re-open the "Doukutsu" application in order to see any changes from the file. In the Windows version, you could simply hit ESC, choose RESET, and reload the game and the changed "profiles.dat" would load. In Mac, the ".plist" file is loaded at the start of the application, so you will need to close and restart (Command-Q, or "File-->Quit") to see your modifications to the file.
If I have time in the next few days (weeks?), I'll try to write a rom-hacking file similar to what has been done already, but with the new offsets.
I hope this helped answer your question. See if you can't find that file: if you have problems, feel free to post here and I'll see if I can't find more explicit instructions.